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Clin Chim Acta 1996:181187 Macallan DC, Noble C, Baldwin C et al (1995) Energy expenditure and wasting in human immunodeficiency virus infection

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Some potential interactions, or circumstances where you want to speak to your doctor before taking extra alpha lipoic supplements, include: You have a thiamine deficiency (vitamin B1), which is associated with liver disease/alcohol abuse

human evidence is largely topical and injectable use is unproven